FemABX peptidyl transferases: a link between branched-chain cell wall peptide formation and beta-lactam resistance in gram-positive cocci.

FemABX Peptidyl Transferases: a Link between Branched-Chain Cell Wall Peptide Formation and -Lactam Resistance in Gram-Positive Cocci

Beta-lactamase induction and cell wall metabolism in Gram-negative bacteria

Production of beta-lactamases, the enzymes that degrade beta-lactam antibiotics, is the most widespread and threatening mechanism of antibiotic resistance. In the past, extensive research has focused on the structure, function, and ecology of beta-lactamases while limited efforts were placed on the regulatory mechanisms of beta-lactamases. Recently, increasing evidence demonstrate a direct link...

Application of a bacterial two-hybrid system for the analysis of protein-protein interactions between FemABX family proteins.

Protein-protein interactions play an important role in all cellular processes. The development of two-hybrid systems in yeast and bacteria allows for in vivo assessment of such interactions. Using a recently developed bacterial two-hybrid system, the interactions of the Staphylococcus aureus proteins FemA, FemB and FmhB, members of the FemABX protein family, which is involved in peptidoglycan b...

مقایسه تاثیر گیاه همیشه‌بهار با سفالوسپورین‌ها بر باکتری‌های جدا شده از بیماران مبتلا به سلولیت

Abstract Background: Presence of the beta-lactamase enzyme results in microbial resistance to beta-lactam and cell wall synthesis inhibitor antibiotics. This study was conducted to compare effects of Calendula officinalis extract and cephalosporines, as a cell wall synthesis inhibitor antibiotic, on bacteria isolated from patients with cellulitis. Methods: This experimental study was done o...

Effects of low PBP2b levels on cell morphology and peptidoglycan composition in Streptococcus pneumoniae R6.

Streptococcus pneumoniae produces two class B penicillin-binding proteins, PBP2x and PBP2b, both of which are essential. It is generally assumed that PBP2x is specifically involved in septum formation, while PBP2b is dedicated to peripheral cell wall synthesis. However, little experimental evidence exists to substantiate this belief. In the present study, we obtained evidence that strongly supp...